Folic acid, also known as folate or Vitamin B9.Folic acid is indicated for the treatment of megaloblastic anaemia because of the folic acid deficiency. It is also used for prophylaxis in chronic haemolytic states, in renal dialysis, and in drug induced folate deficiency.Folic acid is used for the prevention of recurrence of neural tube defects. Folic acid is a vitamin which we use to prevent or treat a deficiency of folic acid in the body. Folic Acid 5mg Tablets is used in the treatment and prevention of certain types of anaemia a low red blood cells. Adequate amounts of vitamin B12 need to be given along with folic acid. Folic acid Tablets can also be given to some women before and during pregnancy to prevent spina bifida an abnormality of the spine in babies, which can be caused by deficiency of this vitamin. IndicationFolic acid is used for the treatment of megaloblastic anaemia because of folic acid deficiency. It is also used for prophylaxis in chronic haemolytic states, in renal dialysis, and in drug induced folate deficiency.PharmacologyMechanism of Action:Folic acid, as it is biochemically inactive, is converted to tetrahydrofolic acid and methyltetrahydrofolate by dihydrofolate reductase (DHFR). These folic acid congeners are transported across cells by receptor-mediated endocytosis where they are needed to maintain normal erythropoiesis, synthesize purine and thymidylate nucleic acids, interconvert amino acids, methylate tRNA, and generate and use formate. Using vitamin B12 as a cofactor, folic acid can normalize high homocysteine levels by remethylation of homocysteine to methionine via methionine synthetase.Pharmacodynamics:
Pharmacodynamics of folic acid is as follows ,the mucosa of the duodenum and upper part of the jejunum are rich in dihydrofolate reductase, where folates and folic acid are absorbed. Once it is absorbed, folic acid is rapidly reduced and then methylated to form tetrahydrofolic acid derivatives which are rapidly transported to the tissues.
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